This issue has recently generated comments. The answer is “no”. As explained by the Supreme Court in Diamond Rubber:
“A patentee may be baldly empirical, seeing nothing beyond his experiments and the result ***. It is certainly not necessary that [the inventor] understand or be able to state the scientific principles underlying his invention ***.”
Diamond Rubber Co. v. Consol. Rubber Tire Co., 220 U.S. 428, 435–36 (1911)
(citations omitted)
Regards,
Hal